The Strange History and Future of Chlamydia Vaccines
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| Chlamydia vaccine picture, google (2) |
The purpose of this article is to provide background on failed attempts to develop a vaccine against Chlamydia, as well as a promising new approach to vaccinating against this disease(1). The difficulty in making a vaccine for Chlamydia is because it is not a species, it is a genus. The human pathogen Chlamydia trachomatis, is the cause for the most common sexually transmitted disease in the United States (3).
The article describes the reason the initial vaccine trials failed. This theory was proposed by Harvard Professor Ulrich von Adrian. Most vaccines are given intramuscularly, which is the reason Dr. von Adrian believes the previous vaccines have failed. Since Chlamydial infections are naturally introduced through the mucous membranes, intramuscular delivery of the vaccine confuses the immune system.
The article does not make it clear whether or not there are publications or specific research that support this, rather, it completely relies on Dr. von Adrian’s word. I suspect that this article was put together in layman terms, and it can be expected that most of the science behind the method of action would be left out.
The article also does not provide support for the mechanism of failure for previous vaccine trials: it simply states that "it confuses the immune system." (1) It references an article that von Adrian published in Science describing the mechanism and success of a vaccine that not only cures infected mice of chlamydia but cures it faster than mice who did not receive the vaccine but had developed natural immunity. The explanation of the effective new vaccine does not relate back to von Adrian’s explanation for the failure of 1960’s chlamydia vaccines, but it offers hope for new strategies in vaccine development.
(2) http://media.gradvet.com/uploads/Chlamydia_Packshots[1][1].JPG
(3) http://web.clark.edu/tkibota/240/Disease/Chlamydia.pdf
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